Molecular Formula | C13H25NO4Si |
Molar Mass | 287.43 |
Density | 1.03±0.1 g/cm3(Predicted) |
Melting Point | 107-109°C(lit.) |
Boling Point | 358.3±27.0 °C(Predicted) |
Specific Rotation(α) | 51 º (c=1, chloroform) |
Flash Point | 170.505°C |
Solubility | almost transparency in Methanol |
Vapor Presure | 0mmHg at 25°C |
Appearance | Whitepowder |
Color | White to Almost white |
pKa | 12.86±0.60(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.464 |
MDL | MFCD00077636 |
Physical and Chemical Properties | Melting Point 107-109°C specific optical rotation 51 ° (c = 1, chloroform) |
Risk Codes | R36 - Irritating to the eyes R43 - May cause sensitization by skin contact R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
Safety Description | S24 - Avoid contact with skin. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37 - Wear suitable gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
UN IDs | UN 3077 9/PG 3 |
WGK Germany | 2 |
HS Code | 29337900 |
Hazard Class | 9 |
Packing Group | III |
Introduction | there are 3 chiral centers and a lactam ring in the structure of 4AA, which are the key and difficult points in the synthesis of 4AA. Early synthesis began with the selection of a suitable and cheap chiral source from natural products for stereo-controlled synthesis. Later, in order to meet the needs of large-scale preparation, semi-synthesis of penicillin and cephalosporin was carried out. In recent years, the total synthesis of 4AA is more active, especially with the development of asymmetric synthesis, many chemists try to use the method of asymmetric synthesis. |
Use | 4-acetoxyazetidinone, hereinafter referred to as 4AA, it is a key intermediate for the synthesis of the drugs of the class of drugs, and has important uses in the pharmaceutical industry. |